Recombinant Human B-Cell Maturation Antigen/TNFRSF17

名称：Recombinant Human B-Cell Maturation Antigen/TNFRSF17

货号：UN402

规格：5μg/20μg/50μg/100μg/500μg/1mg

纯度：>98%

系统：E.coli.

产品详情

Recombinant Human B-Cell Maturation Antigen/TNFRSF17

B-Cell Maturation Antigen (BCMA) , encoded by the TNFRSF17 gene in humans. It is a member of the TNF receptor superfamily and a type III membrane protein containing one extracellular cysteine rich domain. It is expressed on mature B-cells and other B-cell lines. BCMA can binds to TNFSF13B/BLyS/BAFF and TNFSF13/APRIL, and has functions that promotes B-cell survival, plays a role in the regulation of humoral immunity, and activates NF-kappa-B and JNK BCMA.

名称缩写/Abbreviation：

rHuBCMA/TNFRSF17

货号/Item No.：

UN402

别名/Synonyms：

TNFRSF17, BCM, CD269

表达系统/Source：

Expressed in E. coli.

分子量/Molecular Weight：

Approximately 5.4 kDa, a single non-glycosylated polypeptide chain containing 50 amino acids.

SCI的检索号/Accession #：

Q02223 Ala5-Ala54

蛋白序列/A.A. Sequence：

AGQCSQNEYFDSLLHACIPCQLRCSSNTPPLTCQRYCNASVTNSVKGTNA

纯度/Purity：

＞98% by SDS-PAGE or HPLC.

活性/Biological Activity：

Fully biologically active when compared to standard. The ED₅₀ as determined by its ability to inhibit APRIL-mediated proliferation of anti-IgM stimulated murine B cells is no less than 40 ng/ml, corresponding to a specific activity of ≥ 2.5×10⁴ IU/mg in the presence of 100 ng/ml human APRIL.

配方/Formulation：

Lyophilized from a 0.2 μm filtered concentrated solution in 30% acetonitrile, 0.1% TFA.

外观/Appearance：

Sterile filtered White lyophilized (freeze-dried) powder.

内毒素/Endotoxin：

< 0.1 EU/μg of rHuBCMA/TNFRSF17 protein as determined by LAL method.

复溶/Reconstitution：

Before use this product, please read the direction below carefully. This vial must be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in a sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions.

稳定性和存储/Stability & Storage：

For long term storage, the product should be stored ≤ -20℃. Please avoid repeated freeze-thaw cycles after reconstitution. 36 months from date of receipt, -20 to -70℃ as supplied. 1 month, 2 to 8℃ under sterile conditions after reconstitution. 3 months, -20 to -70℃ under sterile conditions after reconstitution.

* THIS PRODUCT IS FOR RESEARCH, LABORATORY AND EVALUATION PURPOSE ONLY.