Recombinant Human Stromal-Cell Derived Factor-1 beta/CXCL12 beta/UN208/rHuSDF-1β/CXCL12β

Recombinant Human Stromal-Cell Derived Factor-1 beta/CXCL12 beta 货号: UN208 规格 :2μg/10μg/50μg/100μg/250μg/500μg/1mg

产品详情：

Recombinant Human Stromal-Cell Derived Factor-1 beta/CXCL12 beta

CXCL12 also known as SDF-1 is belonging to the CXC chemokine family. It is encoded by the CXCL12 gene. In recently study, Human CXCL12 is expressed as six isoforms that differ only in the C-terminal tail. And all SDF-1 isoforms undergo proteolytic processing of the first two N-terminal amino acids. In all SDF-1 isoforms, SDF-1β is the canonical sequence. It has the complete amino acids in the C-terminal tail. On the cell surface, the receptor for this chemokine is CXCR4 and syndecan 4. CXCL12 is strongly chemotactic for T-lymphocytes, monocytes, but not neutrophils. CXCL12 is a very important factor in carcinogenesis and the neovascularization linked to tumor progression. Recombinant human Stromal-Cell Derived Factor-1 beta/CXCL12 beta is an 8.5kDa protein containing 72 amino acid residues.   

名称缩写/Abbreviation： 

rHuSDF-1β/CXCL12β 

 货号/Item No.： 

UN208   

表达系统/Source： 

Expressed in E. coli. 

 分子量/Molecular Weight： 

Approximately 8.5 kDa, a single non-glycosylated polypeptide chain containing 72 amino acids.   

SCI的检索号/Accession #： 

P48061 Lys22-Met93   

蛋白序列/A.A. Sequence： 

KPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNKRFKM 

 纯度/Purity： 

＞97% by SDS-PAGE or HPLC.   

活性/Biological Activity： 

Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using PHA and rHuIL-2 activated human peripheral blood T-lymphocytes is in a concentration range of 20-80 ng/ml.   

配方/Formulation： 

Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4. 

 外观/Appearance： 

Sterile filtered White lyophilized (freeze-dried) powder.   

内毒素/Endotoxin： 

< 0.1 EU/μg of rHuSDF-1β/CXCL12β protein as determined by LAL method.   

复溶/Reconstitution： 

Before use this product, please read the direction below carefully. This vial must be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in a sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions. 

 稳定性和存储/Stability & Storage：  For long term storage, the product should be stored ≤ -20℃. Please avoid repeated freeze-thaw cycles after reconstitution. 36 months from date of receipt, -20 to -70℃ as supplied. 1 month, 2 to 8℃ under sterile conditions after reconstitution. 3 months, -20 to -70℃ under sterile conditions after reconstitution.    * THIS PRODUCT IS FOR RESEARCH, LABORATORY AND EVALUATION PURPOSE ONLY.