Recombinant Human Interleukin-38

名称：Recombinant Human Interleukin-38

货号：UN438

规格：2μg/10μg/50μg/100μg/500μg/1mg

纯度：>97%

系统：E.coli.

产品详情

Recombinant Human Interleukin-38

IL-38，belongs to the IL-1 family，expresses in the fetal skin, spleen and tonsil, mostly in the basal epithelia of skin and in proliferating B cells of the tonsil. IL-38 can bind soluble IL-1 receptor type 1 and may be involved in the regulation of adapted and innate immune responses. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36γ-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS) . Two alternatively spliced transcript variants encoding the same Protein have been reported. Recombinant human IL-38 is a 16.9kDa protein containing 152 amino acid residues.

 名称缩写/Abbreviation：

rHuIL-38

货号/Item No.：

UN438

别名/Synonyms：

Interleukin 1 family member 10, IL1F10, FIL1-theta, FKSG75, IL-1HY2, IL1-theta

表达系统/Source：

Expressed in E. coli.

分子量/Molecular Weight：

Approximately 16.9 kDa, a single non-glycosylated polypeptide chain containing 152 amino acids.

SCI的检索号/Accession #：

Q8WWZ1 Met1-Trp152

蛋白序列/A.A. Sequence：

MCSLPMARYYIIKYADQKALYTRDGQLLVGDPVADNCCAEKICILPNRGLARTKVPIFLGIQGGSRCLACVETEEGPSLQLEDVNIEELYKGGEEATRFTFFQSSSGSAFRLEAAAWPGWFLCGPAEPQQPVQLTKESEPSARTKFYFEQSW

纯度/Purity：

＞97% by SDS-PAGE or HPLC.

配方/Formulation：

Lyophilized from a 0.2 μm filtered concentrated solution of 20 mM PB, with 150 mM NaCl, pH 6.0.

外观/Appearance：

Sterile filtered White lyophilized (freeze-dried) powder.

内毒素/Endotoxin：

< 0.01 EU/μg of rHuIL-38 protein as determined by LAL method.

复溶/Reconstitution：

Before use this product, please read the direction below carefully. This vial must be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in a sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions.

稳定性和存储/Stability & Storage：

For long term storage, the product should be stored ≤ -20℃. Please avoid repeated freeze-thaw cycles after reconstitution. 36 months from date of receipt, -20 to -70℃ as supplied. 1 month, 2 to 8℃ under sterile conditions after reconstitution. 3 months, -20 to -70℃ under sterile conditions after reconstitution.

* THIS PRODUCT IS FOR RESEARCH, LABORATORY AND EVALUATION PURPOSE ONLY.