Recombinant Human Granulocyte Chemotactic Protein 2/CXCL6

名称：Recombinant Human Granulocyte Chemotactic Protein 2/CXCL6

货号：UN201

规格：5μg/20μg/50μg/100μg/500μg/1mg

纯度：>97%

系统：E.coli.

产品详情

Recombinant Human Granulocyte Chemotactic Protein 2/CXCL6

CXCL6 is a CXC chemokine encoded by the CXCL6 gene, which binds to receptors CXCR1 and CXCR2 to regulate inflammation, immune response, and tumorigenesis. CXCL6 acts as a potent chemoattractant for neutrophils and promotes angiogenesis, playing dual roles in tissue repair and cancer progression

. Notably, it exhibits direct antimicrobial activity against both Gram-positive and Gram-negative bacteria, with 90-fold higher potency compared to CXCL5 and CXCL7

. In cancer biology, CXCL6 drives tumor proliferation and metastasis via the CXCR2-JAK-STAT/PI3K axis, while lipid metabolic reprogramming and neutrophil extracellular trap (NET) formation contribute to immunotherapy resistance in cholangiocarcinoma

. A Mendelian randomization study further revealed its causal link to male infertility, highlighting its potential as a diagnostic biomarker or therapeutic target

. Additionally, CXCL6's anti-angiogenic properties and synergy with other chemokines (e.g., CXCL9/10/11) underscore its multifaceted role in reshaping the tumor immune microenvironment and enhancing antitumor immunity

.

名称缩写/Abbreviation：

rHuGCP-2/CXCL6

货号/Item No.：

UN201

表达系统/Source：

Expressed in E. coli.

分子量/Molecular Weight：

Approximately 7.9 kDa, a single non-glycosylated polypeptide chain containing 72 amino acids.

SCI的检索号/Accession #：

 Vla43-Asn114

蛋白序列/A.A. Sequence：

VLTELRCTCLRVTLRVNPKTIGKLQVFPAGPQCSKVEVVASLKNGKQVCLDPEAPFLKKVIQKILDSGNKKN

纯度/Purity：

＞97% by SDS-PAGE or HPLC.

活性/Biological Activity：

Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human neutrophils is in a concentration range of 10-50 ng/ml.

配方/Formulation：

Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM PB, 50 mM NaCl, pH 7.4.

/Appearance：

Sterile filtered White lyophilized (freeze-dried) powder.

内毒素/Endotoxin：

< 0.01 EU/μg of r HuGCP-2/CXCL6 protein as determined by LAL method.

复溶/Reconstitution：

Before use this product, please read the direction below carefully. This vial must be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in a sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions.

稳定性和存储/Stability & Storage：

For long term storage, the product should be stored ≤ -20℃. Please avoid repeated freeze-thaw cycles after reconstitution. 36 months from date of receipt, -20 to -70℃ as supplied. 1 month, 2 to 8℃ under sterile conditions after reconstitution. 3 months, -20 to -70℃ under sterile conditions after reconstitution.

* THIS PRODUCT IS FOR RESEARCH, LABORATORY AND EVALUATION PURPOSE ONLY.