Recombinant human IGF-BP7/UN415/rHuIGF-BP7/Mac25, AGM, FSTL2, IBP-7, IGFBP-rp1

Recombinant human IGF-BP7 货号 :UN415 规格 :5μg/20μg/50μg/100μg/500μg

产品详情：

Recombinant human  IGF-BP7

IGFBP7 a multifunctional regulatory protein

, is a unique secreted glycoprotein that regulates key biological processes through its distinct structure and functions. It contains an N-terminal IGF-binding domain, a central Kazal-like domain, and a C-terminal immunoglobulin-like domain.

Functionally, IGFBP7 modulates IGF-I/II signaling by binding with low affinity, influencing PI3K-AKT and Ras-MAPK pathways to control cell growth and survival. It exhibits dual roles in angiogenesis - supporting vascular repair while inhibiting tumor angiogenesis. As a tumor suppressor, IGFBP7 induces apoptosis and growth arrest in cancers through both IGF-dependent and independent mechanisms.

Emerging research reveals its roles in metabolic regulation (affecting insulin secretion) and immune modulation (via CD93 interaction). Clinically, IGFBP7 serves as a biomarker for kidney injury and heart failure, with therapeutic potential in diabetes and cancer treatment. These diverse functions make IGFBP7 valuable for research and clinical applications.

名称缩写/Abbreviation：

rHuIGF-BP7

货号/Item No.：

UN415

别名/Synonyms：

Mac25, AGM, FSTL2, IBP-7, IGFBP-rp1

表达系统/Source：

Expressed in E. coli.

分子量/Molecular Weight：

Approximately 26.4 kDa, a single non-glycosylated polypeptide chain containing 256 amino acids.

SCI的检索号/Accession #：

Q16270 Ser27-Leu282

蛋白序列/A.A. Sequence：

SSSDTCGPCEPASCPPLPPLGCLLGETRDACGCCPMCARGEGEPCGGGGAGRGYCAPGMECVKSRKRRKGKAGAAAGGPGVSGVCVCKSRYPVCGSDGTTYPSGCQLRAASQRAESRGEKAITQVSKGTCEQGPSIVTPPKDIWNVTGAQVYLSCEVIGIPTPVLIWNKVKRGHYGVQRTELLPGDRDNLAIQTRGGPEKHEVTGWVLVSPLSKEDAGEYECHASNSQGQASASAKITVVDALHEIPVKKGEGAEL

纯度/Purity：

＞97% by SDS-PAGE or HPLC.

配方/Formulation：

Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM Tris-HCl, with 150 mM NaCl, pH 8.6.

外观/Appearance：

Sterile filtered White lyophilized (freeze-dried) powder.

内毒素/Endotoxin：

< 0.01 EU/μg of rHuIGF-BP7 protein as determined by LAL method.

复溶/Reconstitution：

Before use this product, please read the direction below carefully. This vial must be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in a sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions.

稳定性和存储/Stability & Storage：

For long term storage, the product should be stored ≤ -20℃. Please avoid repeated freeze-thaw cycles after reconstitution. 36 months from date of receipt, -20 to -70℃ as supplied. 1 month, 2 to 8℃ under sterile conditions after reconstitution. 3 months, -20 to -70℃ under sterile conditions after reconstitution.

* THIS PRODUCT IS FOR RESEARCH, LABORATORY AND EVALUATION PURPOSE ONLY.