Recombinant Human Interleukin-31/UN091/ IL31, IL-31, Interleukin31

Recombinant Human Interleukin-31 货号： UN091 规格： 2μg/10μg/50μg/100μg/500μg/1mg

产品详情：

Recombinant Human Interleukin-31

Human IL-31 gene is located on Chr.12. It expresses the IL-31 protein at low levels in the type 2 helper T cells, which exits in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea. This protein shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. IL-31 signals through IL-31 receptor A and Oncostatin M receptor subunits and can activate STAT3 through receptors and maybe involve in skin immunity. It regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Human IL-31 shares only 24% a.a. sequence identity in the mature protein with mouse IL-31. Recombinant IL-31 is a single non-glycosylated polypeptide chain containing 141 amino acids.   名称缩写/Abbreviation：  rHuIL-31 

 货号/Item No.:

UN091   

别名/Synonyms： 

IL31, IL-31, Interleukin31   

表达系统/Source：  Expressed in E. coli.   

分子量/Molecular Weight：  Approximately 15.8 kDa, a single non-glycosylated polypeptide chain containing 141 amino acids.   

SCI的检索号/Accession #：

  Q6EBC2 Ser24-Thr164   

蛋白序列/A.A. Sequence：  SHTLPVRLLRPSDDVQKIVEELQSLSKMLLKDVEEEKGVLVSQNYTLPCLSPDAQPPNNIHSPAIRAYLKTIRQLDNKSVIDEIIEHLDKLIFQDAPETNISVPTDTHECKRFILTISQQFSECMDLALKSLTSGAQQATT 

纯度/Purity： 

＞97% by SDS-PAGE or HPLC.   

活性/Biological Activity： 

Fully biologically active when compared to standard. The specific activity is determined by inducing STAT3 activation using human U-87 MG cells. 5 ng/mL of rHuIL-31 can effectively induce STAT3 activation.   

配方/Formulation： 

Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM PB, with 150 mM NaCl, pH 7.4. 

 外观/Appearance： 

Sterile filtered White lyophilized (freeze-dried) powder.   

内毒素/Endotoxin： 

< 0.01 EU/μg of rHuIL-31 protein as determined by LAL method.   

复溶/Reconstitution：  Before use this product, please read the direction below carefully. This vial must be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in a sterile distilled PBS or aqueous buffer containing 0.1% BSA to a concentration of 0.1-0.5 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions. 

稳定性和存储/Stability & Storage：  For long term storage, the product should be stored ≤ -20℃. Please avoid repeated freeze-thaw cycles after reconstitution. 36 months from date of receipt, -20 to -70℃ as supplied. 1 month, 2 to 8℃ under sterile conditions after reconstitution. 3 months, -20 to -70℃ under sterile conditions after reconstitution.    * THIS PRODUCT IS FOR RESEARCH, LABORATORY AND EVALUATION PURPOSE ONLY.